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Thread: Hydroxychloroquine

  1. Top | #11
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    I am re-posting a section of Yale School of Public Health's statement:
    Dr. Harvey Risch is a distinguished cancer epidemiologist who has opined on the topic of hydroxychloroquine (HCQ) and COVID-19 out-patient therapy. He has written a review article in the American Journal of Epidemiology that cites evidence that he believes supports HCQ use for out-patient infection with SARS-CoV-2. Studies that indicate no effect or harmful effects, Dr. Risch believes, enrolled patients too sick to benefit from HCQ.

    Yale-affiliated physicians used HCQ early in the response to COVID-19, but it is only used rarely at present due to evidence that it is ineffective and potentially risky. The Food and Drug Administration of the U.S. Public Health Service issued the following statement (in part):
    June 15, 2020 Update: Based on ongoing analysis and emerging scientific data, FDA has revoked the emergency use authorization (EUA) to use hydroxychloroquine and chloroquine to treat COVID-19 in certain hospitalized patients when a clinical trial is unavailable or participation is not feasible. We made this determination based on recent results from a large, randomized clinical trial in hospitalized patients that found these medicines showed no benefit for decreasing the likelihood of death or speeding recovery. This outcome was consistent with other new data, including those showing the suggested dosing for these medicines are unlikely to kill or inhibit the virus that causes COVID-19. As a result, we determined that the legal criteria for the EUA are no longer met.
    Note that the first paragraph is all about out-patient. The second paragraph is mostly about in-patient.

    I don't think these distinctions and nuances are part of the zeitgeist.

  2. Top | #12
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    Here is the best summary of not only the evidence that hydroxychloroquine doesn't work, also of why it doesn't work. It doesn't even work in vitro with human lung cells. The initial in vitro results were with monkey kidney cells, which have a different infection route.

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